Oligo (.alpha.-arabinofuranosyl nucleotides) and .alpha.-arabinofuranosyl precursors thereof
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United States of America Patent
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Jan 5, 1993
Grant Date -
N/A
app pub date -
Aug 16, 1990
filing date -
Aug 16, 1990
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Novel oligonucleotides formed from .alpha.-D-arabinofuranosyl nucleoside monomers, including oligonucleotides in which one or more of the monomer units is functionalized, are disclosed herein, as well as functionalized monomeric .alpha.-D-arabinofuranosyl nucleosides and nucleotides. A generic formula for the oligomers is: ##STR1## in which B is a nucleotide base which will vary from one monomeric unit to the next in a preselected oligonucleotide sequence; R is phosphate, phsophorothioate, phosphoramidate, or alkanephosphonate; t is 1 for functionalized monomeric units and zero for the others; W is a chemical linker arm; A is a functional group; and n is the number of monomeric units in the oligomer. The oligomers are useful for diagnostic and chemotherapeutic uses. A novel reaction is also disclosed, in which an .alpha.-D-arabinofuranosyl nucleoside with exposed hydroxyls at the 2'-and 3'-positions is selectively protected at the 2'-position in a single reaction.
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