Stabilized liposome/amphotercin B composition and method
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United States of America Patent
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Jan 19, 1993
Issued Date -
N/A
app pub date -
Dec 14, 1990
filing date -
Sep 27, 1985
priority date (Note) -
Expired
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Abstract
A method of administering a liposome/amphotericin B composition having a predetermined size distribution in 0.2-0.5 micron size range. The method includes preparing a suspension of heterogeneously sized amphotericin B liposomes in an aqueous solution containing at least about 0.5% w/v of membrane-stabilizing agent. After sizing to the desired size distribution, and before the liposome sizes change substantially, the suspension is lyophilized for storage. After reconstituting the lyophilized material, the resulting suspension is administered before a substantial size changes in the liposomes occur.
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