Starch encapsulation of biologically active agents by a continuous process
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United States of America Patent
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Feb 2, 1993
Grant Date -
N/A
app pub date -
Jun 25, 1990
filing date -
Jun 25, 1990
priority date (Note) -
Expired
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Abstract
Biologically active agents to be encapsulated are continuously blended with a starchy material and water, subjected to high-shear mechanical action at a temperature above the gelatinization temperature of starch, and continuously recovered as an insolubilized matrix of starch that entraps discontinuous domains of the agent. Alternatively, the core material to be encapsulated is added and blended with the aqueous dispersion of starch after the starch and water have been subjected to an elevated temperature sufficient to gelatinize the starch. Rate of release of agents to the environment can be controlled by preselecting a set of conditions related to various processing parameters. Encapsulation of biologically active compositons provides protection against degradative environmental conditions, improves safety in handling, and slows the release of such compounds to the surrounding medium.
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