Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages
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United States of America Patent
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Feb 9, 1993
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Nov 21, 1991
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Mar 15, 1985
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Abstract
A polymer composition is disclosed composed of morpholino subunit structures linked together by uncharged, chiral linkages, one-three atoms in length. These chiral linkages join the morpholino nitrogen of one subunit to the 5' exocyclic carbon of an adjacent subunit. Each subunit contains a purine or pyrimidine base-pairing moiety effective to bind by hydrogen bonding to a specific base or base-pair in a target polynucleotide.
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