6'-deoxy-6'-halo-neplanocin A and its production
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United States of America Patent
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Feb 16, 1993
Issued Date -
N/A
app pub date -
Mar 18, 1991
filing date -
Feb 14, 1989
priority date (Note) -
Expired
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Abstract
A compound of the formula ##STR1## wherein A is adenine-9-yl and X is halogen, Preferably iodine, or a pharmaceutically acceptable salt thereof. It is a novel derivative of neplanocin A and has almost the same level of cytotoxic activity. However, it is not inactivated by the action of adenosine deaminase. It is produced by replacing a hydroxyl at position-6' in neplanocin A or 2', 3'-O-protected neplanocin A with halogen by use of a halogenating agent, and when hydroxyl at position-2' or -3' is protected, removing the protective group thereof.
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