Amphotericin B/cholesterol sulfate composition and method
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United States of America Patent
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Mar 16, 1993
Issued Date -
N/A
app pub date -
Dec 19, 1991
filing date -
Aug 8, 1989
priority date (Note) -
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Abstract
An amphotericin B composition containing particles of amphotericin B and cholesterol sulfate, in a molar ratio of between about 1:1 to 2:1. The particles, when stored in lyophilized form and reconstituted in an aqueous suspension, have particle sizes predominantly between about 50-250 nm. The composition has stable particle sizes in an aqueous suspension over a several-day storage period. The composition is significantly less toxic and more effective in treating fungal infection than prior amphotericin B formulations.
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