Inhibition of influenza virus replication by oligonucleotide phosphorothioates
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United States of America Patent
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Mar 16, 1993
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N/A
app pub date -
Apr 30, 1990
filing date -
May 23, 1986
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Abstract
A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hydridze to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides.
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