Inclusion complexes with silybinin, their preparation and pharmaceutical compositions containing them
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United States of America Patent
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Mar 30, 1993
Grant Date -
N/A
app pub date -
Oct 9, 1990
filing date -
Oct 9, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention relates to inclusion complexes of Silybinin with a cyclodextrin selected from the group consisting of .alpha.-, .beta.- and .gamma.-cyclodextrin and a suitable derivative thereof and to the method for the preparation thereof. The inclusion complexes of Silybinin showed a highly improved bioavailability in comparison to Silybinin which makes them particularly interesting in the treatment of various hepatotoxic conditions.
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