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Abstract

A process for covalently bonding biopolymer, such as protein, to an organic polymer surface coated with hydrophilic nonionic polymer having groups reactive with the biopolymer, which comprises reacting biopolymer with the surface in a nonpolar reaction medium, preferably a microemulsion, containing from about 0.5 to about 25% water by weight, having a dielectric constant less than 10% of the dielectric constant of pure water; and the product comprises a biopolymer immobilized on a hydrophilic solid surface having a nonionic polymer and a hydrophilic layer, coupled thereto via biopolymer-reactant groups of the nonionic polymer, and accordingly has low spontaneous adsorption of proteins and other biopolymers through electrostatic attraction and/or hydrophobic interaction.

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First Claim