Proteases causing abnormal degradation of amyloid .beta.-protein precursor
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Apr 6, 1993
Issued Date -
N/A
app pub date -
Apr 5, 1991
filing date -
Aug 17, 1990
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A proteolytic factor is capable of cleaving .beta.-protein precursor at a site near the .beta.-protein N-terminus. Also, a method for treating Alzheimer's disease in a patient includes steps of reducing .beta.-protein precursor proteolysis outside the .beta.-protein domain at a site near the .beta.-protein N-terminus. Also, a method for purifying an enzyme from a sample includes steps of incubating the sample with a labelled substrate of the enzyme or with a labelled fragment of a substrate to which the enzyme binds, treating the sample with a crosslinking agent to crosslink any enzyme-substrate complexes in the sample, and recovering labelled complexes. Also, a method for diagnosis in a subject of a disease characterized by accumulation of amyloid includes determining the level, in a sample of tissue or body fluid from the subject, of an AD proteolytic factor. Also, a method for screening for an agent useful in treatment of a disease characterized by accumulation of amyloid includes steps of incubating an AD protease with a peptide having an amino acid sequence corresponding to the sequence spanning the .beta.-protein N-terminus in the presence of a candidate agent, and determining the degradation of the peptide.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully