Thrombin-activated tissue plasminogen activators
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United States of America Patent
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Apr 6, 1993
Grant Date -
N/A
app pub date -
May 22, 1987
filing date -
May 22, 1987
priority date (Note) -
Expired
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Abstract
Zymogens of proteins having fibrinolytic activity are disclosed. The proteins are cleavable by thrombin, the cleavage resulting in the stimulation of fibrinolytic activity. Suitable proteins which may be modified in accordance with the present invention include tissue plasminogen activator, urokinase, and plasminogen variants. The modified molecules are substantially clot-specific, in view of the large amounts of thrombin associated with clots in vivo.
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