Method for inhibiting allograft rejection using photoactivatable nucleotides or nucleosides
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United States of America Patent
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Apr 6, 1993
Grant Date -
N/A
app pub date -
Jul 12, 1991
filing date -
Jul 12, 1991
priority date (Note) -
Expired
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Abstract
Method for inhibiting acute rejection of a transplanted organ or tissue by a recipient mammal that includes the steps of administering to the mammal a compound which causes selective sensitization of the alloreactive lymphocytes of the transplant recipient that are involved in the rejection process to a toxin; and exposing the mammal to the toxin to selectively destroy the sensitized alloreactive lymphocytes to a greater extent than non-sensitized cells of the mammal. This method induces donor specific tolerance in the transplant recipient, i.e., acceptance of the new organ or tissue without suppression of the rest of the recipient's normal immune system.
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