Heterobicyclic containing benzene sulfonamides which are platelet activating factor antagonists
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United States of America Patent
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Apr 6, 1993
Issued Date -
N/A
app pub date -
Aug 15, 1991
filing date -
Aug 15, 1990
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Abstract
Compounds of general formula I; ##STR1## wherein: A.sup.1 is .dbd.N--, .dbd.CH-- or .dbd.CR.sup.1 --; A.sup.2 is --N.dbd., --CH.dbd. or --CR.sup.2 .dbd.; provided that, when one of A.sup.1 and A.sup.2 is a nitrogen atom, the other of A.sup.1 and A.sup.2 is other than a nitrogen atom; the rest of the variables are described in the specification; and their pharmaceutically and veterinarily acceptable acid addition salts and hydrates are antagonists of platelet activating factor (PAF) and as such are useful in the treatment or amelioration of various diseases or disorders mediated by PAF.
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