Process for preparing new thymopentin retro-inverso analogs and fragments thereof and the intermediates obtained therein
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United States of America Patent
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Apr 6, 1993
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N/A
app pub date -
Jan 31, 1991
filing date -
Mar 19, 1987
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Expired
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Abstract
New retro-inverso analogs of thymopentin (TP5) and of its tripeptide fragment (TP5.sup.1-3) of general formula (I) ##STR1## are described wherein R is hydrogen or an acyl radical, and R.sup.1 is --OR.sup.2 or ##STR2## wherein R.sup.2 is hydrogen or a hydrocarbyl radical, and the corresponding pharmaceutically acceptable acid- or base-addition salts. A process of preparing the tripeptide fragment of formula I is also described. The new compounds are enzyme-resistant immunomodulatory peptides.
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