Sustained release pharmaceutical composition
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United States of America Patent
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Apr 13, 1993
Issued Date -
N/A
app pub date -
Aug 24, 1990
filing date -
Jan 6, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The present invention relates to a pharmaceutical pellet composition having a core element including at least one highly soluble active ingredient and a core coating which is partially soluble at a highly acidic pH. The pharmaceutical composition provides a slow release of active ingredient at a highly acidic pH and provides a constant, relatively faster rate of release at a more alkaline pH such as that of the intestine. Oral administration of the pharmaceutical pellet composition of the present invention to a patient is effective to deliver to the blood levels of active ingredient within the therapeutic range and to maintain such levels over an extended period of time.
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