Process for improving mass transfer in a membrane bioreactor and providing a more homogeneous culture environment
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United States of America Patent
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Apr 13, 1993
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N/A
app pub date -
Oct 11, 1990
filing date -
Oct 11, 1990
priority date (Note) -
Expired
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Abstract
A process for improving mass transfer in a bioreactor having at least one semi-permeable membrane defining first and second chambers on opposite sides of the membrane provides for circulating a first media including nutrients and the like through the first chamber and for circulating a second media for cell culture through the second chamber of the bioreactor. The first and second media may be circulated through a plurality of bioreactors connected in parallel while balancing the flow in each reactor. The flow in the second circuit can be periodically reversed to provide increased cell culture.
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