Method and apparatus for determination of chemical species in body fluid
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United States of America Patent
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Apr 20, 1993
Issued Date -
N/A
app pub date -
Aug 15, 1990
filing date -
Sep 8, 1988
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed is a method and apparatus for the non-invasive determination of one or more preselected analytes in a body fluid expressed through the skin. The fluid is collected in a dermal concentration patch and concentrated by driving off a portion of the substantial water fraction under the influence of body heat. The analyte is optimally complexed with an immobilized specific binding partner and an indicium of the presence of the analyte is visually expressed. The patch may comprise a plurality of test zones for screening for a plurality of analytes. Additional positive and negative control zones are also disclosed. The patch may comprise a feature to detect tampering with the patch to produce false negative results, especially when used in screens for drugs of abuse. In addition to being useful as a drug of abuse screen, the patch is useful for diagnostic purposes.
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