Recombinant poxvirus internal cores
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United States of America Patent
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Apr 20, 1993
Grant Date -
N/A
app pub date -
Feb 14, 1990
filing date -
Feb 14, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
What is described is a modified recombinant poxvirus, such as vaccinia virus, fowlpox virus and canarypox virus, having an internal core containing DNA from a non-pox source in a nonessential region of the poxvirus genome. The recombinant poxvirus is modified by disassociating the internal core from outer membranes of the poxvirus. The DNA codes for and expresses a gene product in a cell cultured in vitro and in a host in vivo without productive replication of the virus in the cell or in the host. What is also described is a vaccine containing the modified recombinant poxvirus for inducing an immunological response in a host inoculated with the vaccine.
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