Coupling of an anti-tumor to an antibody using glutaraldehyde preactivated anti-tumor agent
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United States of America Patent
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May 4, 1993
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app pub date -
Jan 13, 1992
filing date -
Aug 10, 1989
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Abstract
The present invention relates to antitumor compounds of the formula I: ##STR1## wherein M is selected from the group consisting of an hydrogen atom, a peptide residue, and a protein residue linked to the carbon atom via the amino residue of .epsilon.-lysine present therein which can be an antibody used to target the anti-tumor agent to the malignant cells, and R can be an antitumor agent such as daunorubicin, doxorubicin, or an epirublicin derivative.
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