Method for separating and purifying polyene macrolide antibiotics
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United States of America Patent
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May 11, 1993
Grant Date -
N/A
app pub date -
Feb 2, 1990
filing date -
Feb 2, 1990
priority date (Note) -
Expired
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Abstract
The present invention provides for the first time an expeditious method to separate polyene macrolide antibiotics into their major components, through a general preparatory procedure employing high pressure liquid chromatography. The procedure allows for the first time a useable preparatory method for separating the polyene macrolide complexes derived from fermentation and cultivation of various organisms, into their major components. Substantially pure dermostatic A and dermostatic B can now be achieved as well as substantially pure mycoticin A and mycoticin B.
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