Preparation of pharmaceutical and other matrix systems by solid-state dissolution
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United States of America Patent
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Jun 1, 1993
Issued Date -
N/A
app pub date -
Nov 6, 1990
filing date -
Dec 22, 1989
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method is disclosed for preparing pharmaceutical and other matrix systems that comprises solidifying a matrix composition dissolved or dispersed in a first solvent and subsequently contacting the solidified matrix with a second solvent that is substantially miscible with the first solvent at a temperature lower than the solidification point of the first solvent, the matrix components being substantially insoluble in the second solvent, whereby the first solvent is substantially removed resulting in a usable matrix.
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