Receptor polypeptides and their production and uses
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United States of America Patent
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Jun 1, 1993
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N/A
app pub date -
Jun 19, 1991
filing date -
Jun 19, 1991
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Abstract
An isolated TGF-.beta. supergene family (TSF) receptor polypeptide is provided. This polypeptide preferably is an inhibin/activin receptor polypeptide and has at least 75% sequence identity with the mature human inhibin/activin receptor sequence. Also provided is a method for purifying TGF-.beta. supergene family members such as inhibin or activin using the polypeptide, and a method for screening for compounds with TGF-.beta. supergene family member activity by contacting the compound with the polypeptide and detecting if binding has occurred and the compound is active.
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