Method of diagnosing blood clots using fibrin-binding proteins
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United States of America Patent
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Jun 8, 1993
Issued Date -
N/A
app pub date -
Sep 22, 1988
filing date -
Sep 25, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A fibrin-binding protein such as t-PA is labeled with a detectable substance, such as a radionuclide, and administered to a patient for diagnosis of blood clots and for monitoring the dissolution thereof during therapy. The detectable substance preferably is attached to t-PA through linkers which specifically bind to the portion of the t-PA protein responsible for enzymatic activity, thereby diminishing this activity while leaving the fibrin-binding property of the protein intact.
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