Controlled release delivery device for macromolecular proteins
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United States of America Patent
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Jun 15, 1993
Issued Date -
N/A
app pub date -
Jul 25, 1991
filing date -
Mar 17, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A controlled release delivery device for macromolecular proteins which comprises a water-soluble outer capsule completely surrounding an inner compartment containing a plurality of non-uniform beadlets. The beadlets comprise a rupturable wax shell which completely surrounds a core matrix containing the macromolecular proteins and optional 'core agents' such as excipients, stabilizers, binders, surfactants, preservatives, or mixtures thereof, and the like. The water-soluble outer capsule dissolves when the device is administered to an animal and simultaneously exposes substantially all of the beadlets to an aqueous environment. Each beadlet absorbs fluid from the environment and separately ruptures over a prolonged period thus delivering the macromolecular protein to the animal.
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