DNA sequence useful for the detection of Alzheimer's disease
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United States of America Patent
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Jun 15, 1993
Issued Date -
N/A
app pub date -
Nov 30, 1989
filing date -
Nov 17, 1986
priority date (Note) -
Expired
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Abstract
DNA sequences encoding the beta-amyloid core protein, and beta-amyloid-related proteins associated with Alzheimer's disease are disclosed. These sequences are used in producing or constructing recombinant beta-amyloid core protein, beta-amyloid-related proteins and recombinant or synthetic immunogenic peptides. These sequences are also used to identify genomic mutations and/or restriction site alterations which are associated with a predisposition to Alzheimer's disease, for purposes of genetic screening. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.
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