Immunometric assays for tumor necrosis factor-alpha and methods for preventing the loss of biological activity of tumor necrosis factor-alpha in biological samples
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United States of America Patent
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Jun 29, 1993
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N/A
app pub date -
Dec 1, 1988
filing date -
Dec 1, 1988
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Abstract
An immunometric assay is disclosed for biologically active tumor necrosis factor in a biological sample comprising, forming a complex of a first labeled monoclonal antibody, biologically active TNF, and a second monoclonal antibody which can be bound to an insoluble substrate and detecting the amount of label associated with the complex. The assay is characterized by employing first and second monoclonal antibodies which react with the same epitopic site on TNF-alpha monomer. A method is also disclosed for blocking accelerated TNF degradation in a non-preserved biological sample, such as blood, comprising contacting the biological sample with EDTA, luminol, or a combination thereof.
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