Soluble HLA cross-match
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United States of America Patent
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Jun 29, 1993
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N/A
app pub date -
Jun 5, 1991
filing date -
Jun 5, 1991
priority date (Note) -
Expired
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Abstract
Soluble HLA cross-matches are determined by providing for antibodies or ligand bound to a solid substrate specific for at least one HLA allele and detecting complexes between either donor or recipient HLA antigens and recipient or donor antibodies, respectively, or reference HLA and patient antibodies, particularly IgG antibodies. Conveniently, anti-human immunoglobulin (Ig), particularly human IgG, conjugates are employed where the anti-human Ig is conjugated with a label capable of providing a detectable signal to permit detection of human anti-HLA bound to said solid substrate.
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