US Patent No: 5,223,482

Number of patents in Portfolio can not be more than 2000

Recombinant Alzheimer's protease inhibitory amyloid protein and method of use

Stats

ATTORNEY / AGENT: (SPONSORED)

Importance

Loading Importance Indicators... loading....

Abstract

See full text

DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid core protein, .beta.-amyloid-related proteins and recombinant or synthetic immunogenic peptides. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

Loading the Abstract Image... loading....

First Claim

See full text

Family

Loading Family data... loading....

Patent Owner(s)

Patent OwnerAddressTotal Patents
SCIOS NOVA INC.MOUNTAIN VIEW, CA30

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cordell, Barbara Palo Alto, CA 35 725
Ponte, Phyllis A Mountain View, CA 2 106
Schilling, Jr James W Palo Alto, CA 9 92

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Bayer Aktiengesellschaft (1)
* 4,595,674 Homologues of aprotinin with, in place of lysine, other aminoacids in position 15, process for their preparation and their use as medicaments 52 1985
 
The Regents of the University of California (1)
* 4,666,829 Polypeptide marker for Alzheimer's disease and its use for diagnosis 277 1985
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
* 4,912,206 CDNA clone encoding brain amyloid of alzheimer's disease 40 1987
* Cited By Examiner

Patent Citation Ranking

Forward Cite Landscape

Patent Info (Count) # Cites Year
 
Other [Check patent profile for assignment information] (5)
* 2003/0194,398 Human bikunin 2 2001
* 2004/0253,643 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-beta peptide (x->41) and tau 4 2004
* 2004/0265,920 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-beta peptide (x->41) and tau 4 2004
* 2006/0024,759 Complex of a chaperone with beta-amyloid and methods employing this complex 1 2005
8,211,658 Complex of a chaperone with β-amyloid and methods employing this complex 0 2011
 
Milkhaus Laboratory, Ltd. (1)
6,174,916 Methods for treating herpes virus infections 8 1998
 
Milkhaus Laboratory, Inc. (4)
* 5,753,624 Materials and methods for treatment of plaquing disease 88 1996
* 5,798,102 Treatment of cardiomyopathy 27 1997
* 5,851,996 Materials and methods for treatment of plaquing diseases 93 1998
6,303,127 Treatment of disease states 4 1998
 
Applied Photonics Worldwide, Inc. (2)
7,816,149 Nanobioprocessor for protein and cell therapy 1 2005
* 2005/0214,380 Nanobioprocessor for protein and cell therapy 1 2005
 
BEALE STREET 143 INVEST APS (2)
7,097,837 Synthetic vaccine agents 21 2002
* 2002/0119,162 Synthetic vaccine agents 0 2002
 
AEROVANCE, INC. (1)
7,452,859 Human bikunin 0 2006
 
NOVARTIS PHARMA AG (1)
7,320,793 Molecular antigen array 15 2002
 
PHARMEXA A/S (1)
* 2004/0191,264 Synthetic vaccine agents 17 2003
 
Eli Lilly and Company (2)
* 6,114,133 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-.beta. peptide (x-.gtoreq.41) 101 1994
* 5,605,811 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 89 1995
 
CYTOS BIOTECHNOLOGY AG (1)
* 2007/0048,287 Molecular antigen array 0 2006
 
CORTEX PHARMACEUTICALS, INC. (1)
* 5,567,724 Alkaline and acid phosphatase inhibitors in treatment of neurological disorders 21 1994
 
Genentech, Inc. (6)
* 5,795,954 Factor VIIa inhibitors from Kunitz domain proteins 31 1994
* 5,880,256 Factor VIIa inhibitors from Kunitz domain proteins 25 1995
* 5,863,893 Factor VIIa inhibitors from kunitz domain proteins 21 1995
* 5,834,244 Factor VIIa inhibitors from Kunitz domain proteins 30 1995
* 5,786,328 Use of kunitz type plasma kallikrein inhibitors 44 1995
* 5,780,265 Kunitz type plasma kallikrein inhibitors 44 1995
 
WACKER CHEMIE AG (1)
* 2008/0254,511 PROCESS FOR THE FERMENTATIVE PRODUCTION OF PROTEINS 2 2007
 
ELAN PHARMACEUTICALS, INC. (3)
* 6,018,024 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 26 1997
7,811,769 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau 4 2004
7,700,309 Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (X->41) and tau 0 2004
 
BAYER CORPORATION (3)
6,583,108 Human bikunin 29 1998
7,019,123 Human bikunin 13 2001
* 2006/0172,946 Human bikunin 0 2006
 
SCIOS INC. (2)
* 5,962,266 Protease inhibitor peptides 37 1997
6,613,890 Protease inhibitor peptides 16 1999
 
H. LUNDBECK A/S (5)
7,135,181 Method for down-regulation of amyloid 17 2001
* 2002/0187,157 Novel method for down-regulation of amyloid 12 2001
* 2009/0092,579 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 1 2008
8,871,212 Amyloid-beta polypeptide vaccine 0 2008
* 2010/0047,262 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 0 2008
 
Holtzman, Jordan L. (1)
7,927,824 Complex of a chaperone with β-amyloid and methods employing this complex 0 2005
 
SCIOS NOVA INC. (2)
6,376,648 Protease inhibitor peptides 29 1999
6,906,033 Protease inhibitor peptides 12 2002
 
Pharnexa A/S (1)
* 2007/0041,945 NOVEL METHOD FOR DOWN-REGULATION OF AMYLOID 3 2006
* Cited By Examiner