US Patent No: 5,223,482

Number of patents in Portfolio can not be more than 2000

Recombinant Alzheimer's protease inhibitory amyloid protein and method of use

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Abstract

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DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid core protein, .beta.-amyloid-related proteins and recombinant or synthetic immunogenic peptides. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SCIOS NOVA INC.MOUNTAIN VIEW, CA41

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cordell, Barbara Palo Alto, CA 40 651
Ponte, Phyllis A Mountain View, CA 2 100
Schilling, Jr James W Palo Alto, CA 9 91

Cited Art Landscape

Patent Info (Count) # Cites Year
 
Bayer Aktiengesellschaft (1)
4,595,674 Homologues of aprotinin with, in place of lysine, other aminoacids in position 15, process for their preparation and their use as medicaments 49 1985
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
4,912,206 CDNA clone encoding brain amyloid of alzheimer's disease 37 1987
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,666,829 Polypeptide marker for Alzheimer's disease and its use for diagnosis 251 1985

Patent Citation Ranking

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Patent Info (Count) # Cites Year
 
Genentech, Inc. (6)
5,795,954 Factor VIIa inhibitors from Kunitz domain proteins 29 1994
5,880,256 Factor VIIa inhibitors from Kunitz domain proteins 23 1995
5,863,893 Factor VIIa inhibitors from kunitz domain proteins 19 1995
5,834,244 Factor VIIa inhibitors from Kunitz domain proteins 28 1995
5,786,328 Use of kunitz type plasma kallikrein inhibitors 39 1995
5,780,265 Kunitz type plasma kallikrein inhibitors 36 1995
 
MILKHAUS LABORATORY, INC. (4)
5,753,624 Materials and methods for treatment of plaquing disease 81 1996
5,798,102 Treatment of cardiomyopathy 23 1997
5,851,996 Materials and methods for treatment of plaquing diseases 87 1998
6,303,127 Treatment of disease states 3 1998
 
ELAN PHARMACEUTICALS, INC. (3)
6,018,024 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 16 1997
7,811,769 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau 4 2004
7,700,309 Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (X->41) and tau 0 2004
 
BAYER CORPORATION (2)
6,583,108 Human bikunin 23 1998
7,019,123 Human bikunin 7 2001
 
Eli Lilly and Company (2)
6,114,133 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-.beta. peptide (x-.gtoreq.41) 86 1994
5,605,811 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 76 1995
 
SCIOS INC. (2)
5,962,266 Protease inhibitor peptides 29 1997
6,613,890 Protease inhibitor peptides 8 1999
 
SCIOS NOVA INC. (2)
6,376,648 Protease inhibitor peptides 23 1999
6,906,033 Protease inhibitor peptides 6 2002
 
AEROVANCE, INC. (1)
7,452,859 Human bikunin 0 2006
 
Applied Photonics Worldwide, Inc. (1)
7,816,149 Nanobioprocessor for protein and cell therapy 1 2005
 
BEALE STREET 143 INVEST APS (1)
7,097,837 Synthetic vaccine agents 9 2002
 
CORTEX PHARMACEUTICALS, INC. (1)
5,567,724 Alkaline and acid phosphatase inhibitors in treatment of neurological disorders 12 1994
 
H. LUNDBECK A/S (1)
7,135,181 Method for down-regulation of amyloid 10 2001
 
Holtzman, Jordan L. (1)
7,927,824 Complex of a chaperone with β-amyloid and methods employing this complex 0 2005
 
Milkhaus Laboratory, Ltd. (1)
6,174,916 Methods for treating herpes virus infections 6 1998
 
NOVARTIS PHARMA AG (1)
7,320,793 Molecular antigen array 8 2002
 
Other [Check patent profile for assignment information] (2)
8,871,212 Amyloid-beta polypeptide vaccine 0 2008
8,211,658 Complex of a chaperone with β-amyloid and methods employing this complex 0 2011