US Patent No: 5,223,482

Number of patents in Portfolio can not be more than 2000

Recombinant Alzheimer's protease inhibitory amyloid protein and method of use

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Abstract

DNA sequences encoding .beta.-amyloid-related proteins associated with Alzheimer's disease are disclosed. Also provided herein is a DNA sequence encoding a novel protease inhibitor. These sequences are used in producing or constructing recombinant .beta.-amyloid core protein, .beta.-amyloid-related proteins and recombinant or synthetic immunogenic peptides. Antibodies generated against the recombinant proteins or immunogenic peptides derived therefrom can be used for cerebral fluid or serum protein diagnosis of Alzheimer's disease.

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First Claim

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Patent Owner(s)

Patent OwnerAddressTotal Patents
SCIOS NOVA INC.MOUNTAIN VIEW, CA41

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cordell, Barbara Palo Alto, CA 35 582
Ponte, Phyllis A Mountain View, CA 2 94
Schilling, Jr James W Palo Alto, CA 9 88

Cited Art

Patent Info (Count) # Cites Year
 
BAYER AKTIENGESELLSCHAFT (1)
4,595,674 Homologues of aprotinin with, in place of lysine, other aminoacids in position 15, process for their preparation and their use as medicaments 43 1985
 
NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT (1)
4,912,206 CDNA clone encoding brain amyloid of alzheimer's disease 33 1987
 
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (1)
4,666,829 Polypeptide marker for Alzheimer's disease and its use for diagnosis 234 1985

Patent Citation Ranking

Forward Cites

Patent Info (Count) # Cites Year
 
GENENTECH, INC. (6)
5,795,954 Factor VIIa inhibitors from Kunitz domain proteins 21 1994
5,880,256 Factor VIIa inhibitors from Kunitz domain proteins 15 1995
5,863,893 Factor VIIa inhibitors from kunitz domain proteins 11 1995
5,834,244 Factor VIIa inhibitors from Kunitz domain proteins 20 1995
5,786,328 Use of kunitz type plasma kallikrein inhibitors 29 1995
5,780,265 Kunitz type plasma kallikrein inhibitors 23 1995
 
MILKHAUS LABORATORY, INC. (4)
5,753,624 Materials and methods for treatment of plaquing disease 72 1996
5,798,102 Treatment of cardiomyopathy 18 1997
5,851,996 Materials and methods for treatment of plaquing diseases 77 1998
6,303,127 Treatment of disease states 3 1998
 
ELAN PHARMACEUTICALS, INC. (3)
6,018,024 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 14 1997
7,811,769 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-β peptide (x-≧41) and tau 4 2004
7,700,309 Methods for aiding in the diagnosis of alzheimer's disease by measuring amyloid-β peptide (X->41) and tau 0 2004
 
BAYER CORPORATION (2)
6,583,108 Human bikunin 11 1998
7,019,123 Human bikunin 3 2001
 
ELI LILLY AND COMPANY (2)
6,114,133 Methods for aiding in the diagnosis of Alzheimer's disease by measuring amyloid-.beta. peptide (x-.gtoreq.41) 78 1994
5,605,811 Methods and compositions for monitoring cellular processing of beta-amyloid precursor protein 70 1995
 
SCIOS INC. (2)
5,962,266 Protease inhibitor peptides 17 1997
6,613,890 Protease inhibitor peptides 3 1999
 
SCIOS NOVA INC. (2)
6,376,648 Protease inhibitor peptides 18 1999
6,906,033 Protease inhibitor peptides 2 2002
 
AEROVANCE, INC. (1)
7,452,859 Human bikunin 0 2006
 
APPLIED PHOTONICS WORLDWIDE, INC. (1)
7,816,149 Nanobioprocessor for protein and cell therapy 0 2005
 
CORTEX PHARMACEUTICALS, INC. (1)
5,567,724 Alkaline and acid phosphatase inhibitors in treatment of neurological disorders 5 1994
 
H. LUNDBECK A/S (1)
7,135,181 Method for down-regulation of amyloid 5 2001
 
HOLTZMAN, JORDAN L. (1)
7,927,824 Complex of a chaperone with β-amyloid and methods employing this complex 0 2005
 
MILKHAUS LABORATORY, LTD. (1)
6,174,916 Methods for treating herpes virus infections 6 1998
 
NOVARTIS PHARMA AG (1)
7,320,793 Molecular antigen array 2 2002
 
PHARMEXA A/S (1)
7,097,837 Synthetic vaccine agents 2 2002
 
OTHER [CHECK PATENT PROFILE FOR ASSIGNMENT INFORMATION] (1)
8,211,658 Complex of a chaperone with β-amyloid and methods employing this complex 0 2011