Recombinant altered antibodies and methods of making altered antibodies
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United States of America Patent
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Jul 6, 1993
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app pub date -
Oct 25, 1991
filing date -
Mar 27, 1986
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Abstract
An altered antibody is produced by replacing the complementarity determining regions (CDRs) of a variable region of an immunoglobulin (Ig) with the CDRs from an Ig of different specificity, using recombinant DNA techniques. The gene coding sequences for producing the altered antibody may be produced by site-directed mutagenesis using long oligonucleotides.
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