Furyl and thienyl substituted taxanes and pharmaceutical compositions containing them
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United States of America Patent
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Jul 13, 1993
Issued Date -
N/A
app pub date -
Apr 3, 1992
filing date -
Sep 23, 1991
priority date (Note) -
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Abstract
A taxane derivative of the formula ##STR1## wherein ##STR2## Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2, T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, R.sub.3 is benzoyl, substituted benzoyl or C.sub.1 -C.sub.6 alkoxycarbonyl, Ac is acetyl, and E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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