Administration of pharmaceutical agents
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United States of America Patent
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-
Jul 20, 1993
Grant Date -
N/A
app pub date -
Nov 28, 1990
filing date -
Nov 28, 1989
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
The bioavailability of pharmaceutical agents susceptible to oxidation of cytochrome P-450, particularly anti-hypertensive dihydropyridines such as felodopine or nifedipine can be increased by administering, before, during or after the administration of the pharmaceutical agent, a flavonoid in the aglycone or glycoside form. This conjoint administration has the effect of prolonging the bioavailability of and so reducing the amount of pharmaceutical agent that needs to be administered. Grapefruit juice has been found to be a suitable source of the flavonoid.
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