Antibodies to dense microspheres
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United States of America Patent
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Jul 27, 1993
Issued Date -
N/A
app pub date -
Jun 14, 1990
filing date -
Aug 27, 1986
priority date (Note) -
Expired
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Abstract
Dense microspheres can be extracted and purified to substantial homogeneity from mammalian brain tissue, and used in the screening of therapies for potential effectiveness in impeding the formation of amyloid fibrils associated with Alzheimer's disease and other forms of cerebral amyloidosis. Compounds that, at in-tissue concentrations of 10.sup.-5 M or less, inhibit amyloid formation in a test animal injected intracerebrally with dense microspheres are particularly useful in inhibiting treating cerebral amyloidosis. Antibodies to DMS (dense microspheres) are also disclosed.
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