Enantiomers of absolute configuration S of amide derivatives of 3-aminoquinuclidine, the process for preparing them and their application in therapy
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United States of America Patent
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Aug 17, 1993
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N/A
app pub date -
Sep 17, 1991
filing date -
Feb 4, 1987
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Abstract
Enantiomer of absolute configuration S of formula: ##STR1## where: X=O or S; and Ar denotes a: * phenyl ring substituted with one, two or three C.sub.1 -C.sub.4 alkoxy groups; * phenyl ring substituted at the 2-position with a OCH.sub.3 group and at the 5-position with a halogen atom or a lower alkylcarbonyl group; * phenyl ring substituted at the 2-position with OCH.sub.3, at the 4-position with NH.sub.2 or alkylcarbonyl-NH and at the 5-position with a halogen; * 3-fluoro-2-methoxyphenyl group; * 5-pyrimidinyl group substituted at the 2-position with NH.sub.2 and in the 4-position with alkoxy or phenyloxy. These compounds are useful as medicinal products having activity in respect of gastric movements and antiemetic activity.
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