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Abstract

A sustained-release pharmaceutical preparation comprising an admixture of uncoated and/or single walled water soluble drug, such as aspirin, and dual walled coated drug. The dual wall structure has an inner wall microencapsular control coating, such as ethyl cellulose, and an outer wall enteric coating such as cellulose acetate phthalate. The dual walled coated drug has a delayed, gradual, long-term release which takes place in the intestines while the uncoated and/or single walled drug has immediate therapeutic properties upon dissolution in the stomach. The outer wall enteric coating may be applied to microencapsulated core drug by a coacervation, spray coating or other process.

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First Claim