Efficient microcapsule preparation and method of use
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United States of America Patent
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Aug 24, 1993
Grant Date -
N/A
app pub date -
Oct 2, 1990
filing date -
Oct 2, 1990
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Expired
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Abstract
The present invention relates to a method of preparing microcapsules suitable for encapsulation of therapeutic and diagnostic agents. The capsular coats are prepared from biodegradable polymers. In a particular aspect of the invention, surface charge of the polymeric material is altered by conjugation of an amino acid ester to the polymer, providing targeting to specific tissue cells. Encapsulation of hydrophilic radiodiagnostic agents in 1 .mu.m capsules provides improved opacification. Encapsulation of cytotoxic agents in 100 .mu.m capsules is useful in chemoembolization procedures.
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