Compositions for photodynamic therapy
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United States of America Patent
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Aug 24, 1993
Issued Date -
N/A
app pub date -
Sep 30, 1991
filing date -
Mar 22, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Methods to prepare intermediates for the conjugation of active ingredients to hydrophilic carriers are described. The polyhydroxylated carriers are first derivatized to convert the hydroxyls to leaving groups and then reacted with an alkylene diamine in the presence of a reducing agent. The resulting derivatized carrier can then be coupled to substituents containing carboxyl groups in the presence of dehydrating agents.
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