Inhibitors of platelet-derived growth factor

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United States of America Patent

PATENT NO 5238950
SERIAL NO

07808997

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ATTORNEY / AGENT: (SPONSORED)

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Abstract

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A method of inhibiting the binding of PDGF using compounds of the formula I ##STR1## useful in the treatment of atherosclerosis, cancer, retinal detachment, pulmonary fibrosis, arthritis, psoriasis and glomerulonephritis, and restenosis following angioplasty or vascular surgery is disclosed. Also disclosed are pharmaceutical compositions and novel PDGF inhibitory compounds of the formula ##STR2## or a pharmaceutically acceptable addition salt thereof, useful in the treatment of atherosclerosis, cancer, retinal detachment, pulmonary fibrosis, arthritis, psoriasis and glomerulonephritis, and restenosis following angioplasty or vascular surgery.

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Patent Owner(s)

Patent OwnerAddress
SCHERING CORPORATION A CORP OF NEW JERSEYGALLOPING HILL ROAD KENILWORTH NJ 07033

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Clader, John W Cranford, NJ 70 1194
Davis, Harry R Berkeley Heights, NJ 25 385
Mullins, Deborra New York, NY 1 89
Rosenblum, Stuart West Orange, NJ 4 127
Weinstein, Jay Upper Montclair, NJ 24 396

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