Automated apparatus for use in peptide synthesis
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United States of America Patent
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Aug 31, 1993
Grant Date -
N/A
app pub date -
Dec 19, 1991
filing date -
Dec 19, 1991
priority date (Note) -
Expired
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Abstract
An automated apparatus for use in cleaving, deprotecting and purifying synthesized polypeptides immobilized on solid phase particles. The apparatus includes cleavage and extraction vessels where peptide cleavage from solid-phase particles, and extraction of scavenger reagents occurs, respectively, and structure for automated transfer of (i) reaction solutions into and out of the cleavage vessel, (ii) peptide solution from the cleavage vessel to the extraction vessel, and (iii) extraction solvent into the extraction vessel, in dispersed form. Excess extraction solvent is removed from a side arm in the extraction vessel.
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