Transdermal therapeutic system comprising as active component buprenorphine
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United States of America Patent
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Aug 31, 1993
Issued Date -
N/A
app pub date -
Sep 24, 1992
filing date -
Nov 29, 1989
priority date (Note) -
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Abstract
The controlled release of buprenorphine or the pharmaceutically acceptable salts thereof to the skin over a period of time of at least 24 hours is ensured by a transdermal therapeutic system consisting of a backing layer which is impermeable to the active substance, a pressure-sensitive adhesive reservoir layer, and optionally a removable protective layer. Said reservoir layer of said system comprises 20 to 90%-wt polymeric material, 0.1 to 30%-wt softener, 0.1 to 20%-wt buprenorphine base or one of the pharmaceutically acceptable salts thereof, and 0.1 to 30%-wt solvent for the active substance base.
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