Solid surface coated with a hydrophilic biopolymer-repellent outer layer and method of making such a surface
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United States of America Patent
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Aug 31, 1993
Grant Date -
N/A
app pub date -
Sep 13, 1991
filing date -
Oct 22, 1990
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A solid surface having anionic groups capable of reacting with a polyethylene imine substituted at least in part by at least 50% by weight of a hydrophilic nonionic polymer having a molecular weight within the range from about 400 to about 200,000 is provided with a hydrophilic biopolymer-repellent outer surface layer thereof by reacting such a polyethylene imine substituted by nonionic hydrophilic polymer with anionic groups on the solid surface, in an amount sufficient to produce biopolymer-repellent solid surface, and accordingly having low spontaneous adsorption of proteins and other biopolymers through electrostatic attraction and/or hydrophobic interaction.
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