Catheter device and method of use for intramural delivery of protein kinase C and tyrosine protein kinase inhibitors to prevent restenosis after balloon angioplasty
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United States of America Patent
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Sep 7, 1993
Issued Date -
N/A
app pub date -
Jan 2, 1992
filing date -
Jun 20, 1989
priority date (Note) -
Expired
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Abstract
The present invention discloses a method of treatment of an atherosclerotic blood vessel. Protein kinase C and tyrosine protein kinase inhibitors are delivered by means of a specialized catheter system to the deeper layers of the vessel wall with only minimal interruption of the vessel endothelium. This system will allow high local concentrations of otherwise toxic agents directly at the site of an atherosclerotic plaque to prevent and/or reduce the incidence of late restenosis attributed to cellular hyperplasia or rethrombosis.
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