Certain alkoxy substituted taxanes and pharmaceutical compositions containing them
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United States of America Patent
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Sep 7, 1993
Issued Date -
N/A
app pub date -
Apr 3, 1992
filing date -
Sep 23, 1991
priority date (Note) -
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Abstract
A taxane derivative of the formula ##STR1## wherein R.sub.1 is phenyl or substituted phenyl, R.sub.3 is CH.sub.3 O--, or CH.sub.3 CH.sub.2 O--, Z is --OT.sub.1, T.sub.1 is hydrogen, hydroxyl protecting group, or --COT.sub.2. T.sub.2 is H, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkenyl, C.sub.1 -C.sub.6 alkynyl or monocylic aryl, Ac is acetyl, and E.sub.1 and E.sub.2 are independently selected from hydrogen and functional groups which increase the water solubility of the taxane derivative are useful as antitumor agents.
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