Preparation for endermism containing dopamine derivatives
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United States of America Patent
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Sep 21, 1993
Issued Date -
N/A
app pub date -
Jul 8, 1992
filing date -
Dec 6, 1989
priority date (Note) -
Expired
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Abstract
(A) a diacylated dopamine derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 3 to 7 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, substituted or unsubstituted phenyl group or a substituted or unsubstituted nitrogen-containing heterocyclic group; and R.sup.2 represents a hydrogen atom or a lower alkyl group; or a salt thereof; and (B) one or more compounds selected from lactic acid esters, fatty acid monoglycerides and higher alcohols; optionally together with (C) an unsaturated fatty acid monohydric alcohol ester. This preparation has a sustained effect, a high skin permeability and a low skin irritativeness.
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