Methods and compositions for treatment of cancer using oligonucleotides
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United States of America Patent
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Sep 28, 1993
Issued Date -
N/A
app pub date -
Dec 9, 1991
filing date -
Feb 15, 1989
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Abstract
The present invention provides methods useful in autologous bone marrow transplantation and cancer therapy. According to one aspect of the invention, bone marrow cells from a patient having cancer are treated with selected antisense oligonucleotides in order to deplete the bone marrow of malignant cells prior to infusion back into the bone marrow donor. In a separate embodiment, selected antisense oligonucleotides are administered systemically for anticancer therapy.
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