Taxol derivatives
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United States of America Patent
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Sep 28, 1993
Grant Date -
N/A
app pub date -
Jun 18, 1992
filing date -
Jun 18, 1992
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to 10-desacetoxy-11,12-dihydrotaxol-10,12(18)-diene derivatives which are useful as antitumor agents and as intermediates for the preparation of 10-desacetoxytaxol. Also disclosed is a novel process for the preparation of 10-desacetoxytaxol which comprises treating hydroxy protected 10-deacetyltaxol with 1,1,2-trifluoro-2-chlorotriethylamine followed by catalytic hydrogenation.
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