Controlled release calcium channel blocker microcapsules
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United States of America Patent
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Oct 12, 1993
Grant Date -
N/A
app pub date -
Jun 25, 1991
filing date -
Jun 25, 1991
priority date (Note) -
Expired
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Abstract
A controlled release formulation of a calcium channel blocker for oral administration contains non-pareil seeds loaded with a calcium channel blocker, particularly diltiazem, nifedipine, or verapamil, and then microencapsulated in ethylcellulose by phase separation techniques. The resultant microcapsules provide an approximately zero order release rate, preferably over 12 to 16 hours. These microcapsules may be filled into gelatin capsules.
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