Hydroxyquinolone derivatives

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United States of America Patent

PATENT NO 5252584
SERIAL NO

07801998

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Abstract

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A class of 4-hydroxy-2(1H)-quinolone derivatives, substituted at the 3-position by an N-linked heteroaromatic ring system, are selective non-competitive antagonists of NMDA receptors and/or are antagonists of AMPA receptors, and are therefore of utility in the treatment of conditions, such as neurodegenerative disorders, convulsions or schizophrenia, which require the administration of an NMDA and or AMPA receptor antagonist.

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Patent Owner(s)

Patent OwnerAddress
MERCK SHARP & DOHME LTDHODDESDON

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Carling, William R Bishops Stortford, GB2 32 200
Leeson, Paul D Cambridge, GB2 27 524
Moore, Kevin W Buntingford, GB2 50 693

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