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Abstract

Novel chelating compounds and the corresponding radionuclide metal chelates are useful for radiolabeling proteins such as antibodies with radionuclide metals such as .sup.99m Tc, .sup.186 Re, and .sup.188 Re. The chelating compounds are of the following formulas: ##STR1## wherein each R is a protecting group; Q is hydrogen or a protecting group; each T is independently chosen from hydrogen, lower alkyl groups of from 1 to about 6 carbon atoms, electron withdrawing groups, and lower alkyl groups of from 1 to about 6 carbon atoms substituted with electron withdrawing group(s); X represents O, S, or NH; each R' is independently selected from: --(CH.sub.2).sub.n --COOH with n=0 to about 4, --(CH.sub.2).sub.n --Z, wherein Z represents a conjugation group and n is 0 to about 4, hydrogen, and a lower alkyl group of from 1 to about 6 carbon atoms; each R' is independently selected from: --(CH.sub.2).sub.n --COOH, with n=0 to about 4, hydrogen, and a lower alkyl group of from 1 to about 6 carbon atoms; and the compound comprises at least one --(CH.sub.2).sub.n --Z substituent. The conjugation group Z reacts with a protein to bind the chelating compound thereto. The radiolabeled proteins have diagnostic or therapeutic use, depending on the radionuclide metal chosen.

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