Combination of pravastatin and nicotinic acid or related acid and method for lowering serum cholesterol using such combination
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United States of America Patent
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Nov 9, 1993
Issued Date -
N/A
app pub date -
Jun 18, 1992
filing date -
Dec 12, 1988
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Abstract
A pharmaceutical combination is provided which includes an inhibitor of the enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, which is pravastatin and a pharmaceutical which reduces serum cholesterol and/or inhibits cholesterol biosynthesis by a mechanism other than inhibiting production of the enzyme HMG CoA reductase, namely, nicotinic acid (niacin) or related acid. A method for reducing serum cholesterol or inhibiting formation of or treating atherosclerosis using the above combination without causing drug-induced myopathy or rhabdomyolysis, is also provided.
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