Transdermal nitroglycerin patch with penetration enhancers
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United States of America Patent
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Nov 16, 1993
Grant Date -
N/A
app pub date -
Feb 4, 1992
filing date -
Feb 4, 1992
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A transdermal nitroglycerin patch exhibiting superior nitroglycerin skin penetrating characteristics comprising a percutaneous penetration enhancer is disclosed, wherein the penetration enhancer may be one or more of N-methyl-2-pyrrolidone, oleic acid, oleyl butanediol, linoleic acid, isopropyl linoleate, azone and alcohol. Also disclosed is a transdermal patch design comprising two concentric rings, wherein the concentrations of nitroglycerin and the permeability enhancer are varied.
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